Key words : Nanoparticles, microparticles, Pickering emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis
The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical engineering) is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.
The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.
Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.
Director of the Pharmaceutical Engineering, Professeur Bolzinger
- Giovanna LOLLO joins the editorial board of the Journal of Controlled Release!
- Two new awards for @LAGEPP at the CRS BNLF Early Career Scientist Meeting, 6th April 2021
- Vote for the video presentation of the RESOLVE project
- A video presenting the RESOLVE project is on line.
- New collaboration between Skyepharma and LAGEPP Laboratory of Université Claude Bernard Lyon 1 and CNRS
- BARCamp Workshop : Mathieu Repellin (LAGEPP) and Mary Varoux (LBBE)
- “Highly Cited Researchers” : 4 researchers from Lyon, 2 from #LAGEPP
- COSLIFE platform
First conference Brillouin Light Scattering
This conference is dedicated to the discussion of advances in the field of Brillouin Light Scattering Microspectroscopy for Biological and…Continue reading »
Thesis Defense: Maroua ROUABAH
Maroua ROUABAH is pleased to invite you to her thesis defense entitled “Experimental study and modeling of the wet pelletizing…Continue reading »
Thesis defense: Marine Leroux
Marine Leroux is pleased to invite you to her thesis defense: “Role of polyunsaturated fatty acids and bis(monoacylglycero)phosphate in Leishmania…Continue reading »
Webinar Société Chimique de France: Alex Kerr
The Formulation group of the Société Chimique de France offers free webinars. The next one will take place from 1pm…Continue reading »
La BU donne carte blanche à Yves Chevalier
All informationsContinue reading »
Seminar : Dr. Koen van der Maaden
Dr. Koen van der Maaden from the Leiden University Medical Center (LUMC) will visit the LAGEPP and present a talk…Continue reading »
Lollo Giovanna’s HDR
On November 8th at 3pm in the ISPB Thesis Room, Lollo Giovanna will defend her HDR on the subject: “Overcoming…Continue reading »
Symposium: Nanomedicine and immunology to develop novel therapeutic approaches
In the context of the project NanoImmune funded by the Arqus program, we organize the 14th and 15th of October…Continue reading »
Seminar: Philippe, Samira, Isabelle and Céline
Our colleagues, Philippe Samira, Isabelle and Céline, will give a seminar to present their research activities on Thursday 21 October…Continue reading »
Seminar: Pr. Ana Grenha
Pr. Ana Grenha from the University of Algarve in Portugal. will give a talk titled: “Inhalable therapies: Valuable tools in…Continue reading »
- Projet Maturation : NanoNeb-UP
- Nano-Immune : Nanomedicine-mediated immune modulation to treat glioblastoma
- Development of a diagnostic approach for imaging a ligand of dependent receptors.
- Techniques and modern processes of impregnation of nanocapsules in leather
- METAVAC-T17: Characterization and up-scaling of a DuckCeltTM-T17 cell suspension culture process for the production of a new live-attenuated HRSV/HMPV chimeric METApneumovirus-based VACcine
- PeptiCaps: european project
- EURONANOMED III european project: RESOLVE
- ANR – AAPG 2018 JCJC: HyDNano
- ADEME project: ECLA
- ANR ASTRID-MATURATION DENOTER
Find all the projects on the GEPHARM Projects page
- Master 2 : 6 months internship offer Formulation of polyoxometalate as imaging contrast agent
- Thesis: Enabling local immune modulation using gene-based nanomedicine for the treatment of Inflammatory Bowel Diseases
- Post-Doc: Design of nanocomposites for drug delivery application
- Laboratory technician, chemical profile, analysis, formulation, processes
- Bis(monoacylglycerol)phosphate, a putative regulator of Leishmania virulence towards macrophages
- PhD offer: Experimental study and modelling of freeze-drying cycles of a model probiotic strain of type L. Casei
- PhD offer: Stabilization of Pickering emulsions by association of polymeric particles
- PhD offer: New delivery approach targeting macrophages for active anti-tumor immunotherapy
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Year of production
- Khawla Mili, Zouhour Hsine, Yves Chevalier, Gilles Ledoux, Rym Mlika. Application of thiol capped ZnS quantum dots as a fluorescence probe for determination of tetracycline residues. Solid State Communications, 2023, 360, pp.115040. ⟨10.1016/j.ssc.2022.115040⟩. ⟨hal-03905050⟩
- Maroua Ben Abdelkader, Nedra Azizi, Ayda Baffoun, Claire Bordes, Yves Chevalier, et al.. Application of an experimental design methodology for the optimization of cosmetotextile impregnation process by β-cyclodextrin based microcapsules. Journal of the Textile Institute, 2023, 114 (2), pp.314-322. ⟨10.1080/00405000.2022.2031710⟩. ⟨hal-03951166⟩
- Merymene Boukadida, Najeh Jaoued-Grayaa, Amira Anene, Yves Chevalier, Souhaira Hbaieb. Effect of cross-linking agents on the adsorption of histamine on molecularly imprinted polyacrylamide. Polymer, 2023, 268, pp.125724. ⟨10.1016/j.polymer.2023.125724⟩. ⟨hal-03955548⟩
- Thibault Massias, Suenia de Paiva Lacerda, Jacqueline Resende de Azevedo, Jean‐jacques Letourneau, Marie-Alexandrine Bolzinger, et al.. Supercritical carbon dioxide solubility measurement and modelling for effective size reduction of nifedipine particles for transdermal application. International Journal of Pharmaceutics, 2023, 630, pp.122425. ⟨10.1016/j.ijpharm.2022.122425⟩. ⟨hal-03875943⟩
- Noureddine Lebaz, Nida Sheibat-Othman. Population balance modelling of a continuous static mixer-based emulsification process. Chemical Engineering Research and Design, 2022, 188, pp.645-654. ⟨10.1016/j.cherd.2022.10.022⟩. ⟨hal-03815945⟩
- Eslam Elkalla, Sumera Khizar, Nadia Zine, Nicole Jaffrezic-Renault, Noureddine Lebaz, et al.. Elaboration of iron oxide capsules for lab-on-a-chip and microsystems use. 12ème Journées Maghreb-Europe: Matériaux et applications aux dispositifs et capteurs, Nov 2022, Monastir, Tunisia. ⟨hal-03859546⟩
- Noureddine Lebaz, Kristy Touma, Nida Sheibat-Othman. Modélisation par bilan de population de la formation d’émulsions doubles par des mélangeurs statiques. 18ème Congrès de la Société Française de Génie des Procédés, Nov 2022, Toulouse, France. ⟨hal-03848924⟩
- Karima Ferchichi, Noureddine Amdouni, Yves Chevalier, Souhaira Hbaieb. Low-cost Posidonia oceanica bio-adsorbent for efficient removal of antibiotic oxytetracycline from water. Environmental Science and Pollution Research, 2022, 29 (55), pp.83112-83125. ⟨10.1007/s11356-022-21647-3⟩. ⟨hal-03873732⟩
- Denise Cardoso, Agnès Narcy, Stéphane Durosoy, Yves Chevalier. The pH dependence of dissolution kinetics of zinc oxide. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 650, pp.129653. ⟨10.1016/j.colsurfa.2022.129653⟩. ⟨hal-03721083⟩
- Najeh Jaoued-Grayaa, Chaima Nasraoui, Yves Chevalier, Souhaira Hbaieb. Design of molecularly imprinted polymer materials relying on hydrophobic interactions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 647, pp.129008. ⟨10.1016/j.colsurfa.2022.129008⟩. ⟨hal-03655857⟩