Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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964 documents

  • Meryem Belkilani, Carole Farre, Yves Chevalier, Sylvain Minot, François Bessueille, et al.. Mechanisms of Influenza Virus HA2 Peptide Interaction with Liposomes Studied by Dual-Wavelength MP-SPR. ACS Applied Materials & Interfaces, 2022, ⟨10.1021/acsami.2c09039⟩. ⟨hal-03730479⟩
  • C. Kalakech, C. Charcosset, Mathias Monnot, E. Gagnière, Denis Mangin, et al.. Procédé continu et intensifié de cristallisation membranaire : Contrôle de la qualité d’un principe actif pharmaceutique. MEMPRO 7, Jun 2022, Montpellier, France. ⟨hal-04050077⟩
  • Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Isabelle Ramière, Denis Mangin, Murielle Bertrand. Solution du bilan de population à l’état stationnaire dans le contexte de la précipitation oxalique dans un réacteur à effet vortex. Cristal 10, Jun 2022, Lyon, France. ⟨hal-03694122⟩
  • Jean Tallon, E. Gagnière, Claire Bordes, Géraldine Agusti, Yves Chevalier, et al.. Etude expérimentale de la transition de phase du carbonate de calcium de l’amorphe aux forms cristallines en emulsion inverse. CRISTAL 10, Jun 2022, Lyon, France. ⟨hal-03701102⟩
  • Adithya Ramanathan Krishnan, Noureddine Lebaz, C. Charcosset, E Chabanon. BaCO3 precipitation using a dense membrane contactor : 1D population balance modelling. Cristal 10, Jun 2022, Lyon, France. ⟨hal-03694118⟩
  • Ayoub Ouarga, Noureddine Lebaz, Mohamad Tarhini, Hassan Noukrati, Allal Barroug, et al.. Towards smart self-healing coatings: Advances in micro/nano-encapsulation processes as carriers for anti-corrosion coatings development. Journal of Molecular Liquids, 2022, 354, pp.118862. ⟨10.1016/j.molliq.2022.118862⟩. ⟨hal-03604321⟩
  • Noureddine Lebaz, Nida Sheibat-Othman. Population balance modelling of single and double emulsions preparation using static mixers. 7th International Conference on Population Balance Modelling, May 2022, Lyon, France. ⟨hal-03668994⟩
  • Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Isabelle Ramière, Denis Mangin, Murielle Bertrand. Steady state population balance solution: application to neodymium oxalate precipitation in a vortex reactor. 7th International Conference on Population Balance Modelling, May 2022, Lyon, France. ⟨hal-03669016⟩
  • Soumaya Kouki, Najeh Jaoued-Grayaa, Amira Anene, Emmanuel Beyou, Yves Chevalier, et al.. The enhanced adsorption properties of molecular imprinted polymer material prepared using nitroxide-mediated Radical Deactivation Reversible Polymerization. Polymer, 2022, 249, pp.124841. ⟨10.1016/j.polymer.2022.124841⟩. ⟨hal-03654008⟩
  • Mariane Massufero Vergilio, Laura Moretti Aiello, Andreza Sonego Furlan, Amanda Costa Caritá, Jaqueline Rezende Azevedo, et al.. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound. Journal of Cosmetic Dermatology, 2022, 21 (10), pp.4921-4926. ⟨10.1111/jocd.14892⟩. ⟨hal-03835488⟩

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