Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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962 documents

  • Abdelhamid Elaissari, Francois Ganachaud, Christian Pichot. Biorelevant Latexes and Microgels for the Interaction with Nucleic Acids. book series (TOPCURRCHEM, volume 227), pp.169-193, 2003, ⟨10.1007/3-540-36412-9_7⟩. ⟨hal-02093936⟩
  • R. P Baptista, A.M Santos, A Fedorov, J. M. G Martinho, A. Elaissari, et al.. Activity, conformation and dynamics of cutinase adsorbed on poly(methyl methacrylate) latex particles. African Journal of Biotechnology, 2003, 102 (3), pp.241-249. ⟨10.1016/S0168-1656(03)00033-6⟩. ⟨hal-02093472⟩
  • Alix Dubes, Helene Parrot-Lopez, Wassim Abdelwahed, Ghania Degobert, Hatem Fessi, et al.. Scanning electron microscopy and atomic force microscopy imaging of solid lipid nanoparticles derived from amphiphilic cyclodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 2003, 55 (3), pp.279-282. ⟨10.1016/S0939-6411(03)00020-1⟩. ⟨hal-02059543⟩
  • Tatsuo Taniguchi, David Duracher, Thierry Delair, Abdelhamid Elaïssari, Christian Pichot. Adsorption/desorption behavior and covalent grafting of an antibody onto cationic amino-functionalized poly(styrene-N-isopropylacrylamide) core-shell latex particles. Colloids and Surfaces B: Biointerfaces, 2003, 29 (1), pp.53-65. ⟨10.1016/S0927-7765(02)00176-5⟩. ⟨hal-02093923⟩
  • Carole Chaix, Elodie Pacard, Abdelhamid Elaïssari, Jean-François Hilaire, Christian Pichot. Surface functionalization of oil-in-water nanoemulsion with a reactive copolymer: colloidal characterization and peptide immobilization. Colloids and Surfaces B: Biointerfaces, 2003, 29 (1), pp.39-52. ⟨10.1016/S0927-7765(02)00177-7⟩. ⟨hal-02093882⟩
  • Y Deng, L. Wang, Y Yang, S Fu, A Elaïssari. Preparation of magnetic polymeric particles via inverse microemulsion polymerization process. Journal of Magnetism and Magnetic Materials, 2003, 257 (1), pp.69-78. ⟨10.1016/S0304-8853(02)00987-3⟩. ⟨hal-02093888⟩
  • Franck Montagne, Sébastien Braconnot, Olivier Mondain‐monval, Christian Pichot, Abdelhamid Elaissari. Colloidal and Physicochemical Characterization of Highly Magnetic O/W Magnetic Emulsions. Journal of Dispersion Science and Technology, 2003, 24 (6), pp.821-832. ⟨10.1081/DIS-120025550⟩. ⟨hal-02093909⟩
  • A.-L Le Coënt, Mélaz Tayakout-Fayolle, F. Couenne, S. Briancon, J. Lieto, et al.. Kinetic parameter estimation and modelling of sucrose esters synthesis without solvent. Chemical Engineering Science, 2003, 58 (2), pp.367-376. ⟨10.1016/S0009-2509(02)00474-8⟩. ⟨hal-02432538⟩
  • F Montagne, O. Mondain-Monval, C Pichot, H. Mozzanega, A Elaïssari. Preparation and characterization of narrow sized (o/w) magnetic emulsion. Journal of Magnetism and Magnetic Materials, 2002, 250, pp.302-312. ⟨10.1016/S0304-8853(02)00412-2⟩. ⟨hal-02093878⟩
  • Hazot P., Delair T., Elaïssari A., Chapel P., Pichot C.. Functionalization of poly( N -ethylmethacrylamide) thermosensitive particles by phenylboronic acid. Colloid and Polymer Science, 2002, 280 (7), pp.637-646. ⟨10.1007/s00396-002-0664-5⟩. ⟨hal-02093868⟩

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