Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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964 documents

  • D. Cardoso, A. Romeo, S. Durosoy, N. Même, Yves Chevalier, et al.. Effect of the physicochemical properties of zinc oxide sources on their bioavailability in broilers. British Poultry Science, 2021, 62 (6), pp.846-851. ⟨10.1080/00071668.2021.1940862⟩. ⟨hal-03531165⟩
  • Sundas Khalid, Nasir Ahmad, Sumera Khizar, Gul Shahnaz, Noureddine Lebaz, et al.. Magnetic Polymer Colloids for Ultrasensitive Molecular Imaging. Magnetic Nanoparticles in Human Health and Medicine : Current Medical Applications and Alternative Therapy of Cancer, Wiley, 2021, ‎ 978-1119754671. ⟨hal-03284315⟩
  • Federico Capuana, Alkystis Phinikaridou, Rachele Stefania, Sergio Padovan, Begoña Lavin, et al.. Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin. Journal of Medicinal Chemistry, 2021, 64 (20), pp.15250-15261. ⟨10.1021/acs.jmedchem.1c01286⟩. ⟨hal-03433450⟩
  • Fabrice Ofridam, Noureddine Lebaz, E. Gagnière, Denis Mangin, Abdelhamid Elaïssari. pH-sensitive polymethacrylate derivatives Eudragit E100 & L100 nanoparticles preparation in aqueous medium. 21st International Symposium on Industrial Crystallization, Aug 2021, Postdam, Germany. ⟨hal-03334747⟩
  • Lucas Brivadis, Vincent Andrieu, E Chabanon, E. Gagnière, Noureddine Lebaz, et al.. New soft sensor design for a batch crystallization process based on solute concentration. ISIC, Aug 2021, Postdam, Germany. ⟨hal-04049465⟩
  • Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Denis Mangin, Murielle Bertrand, Elie Saikali, et al.. A compartmental-based approach for the modelling of a vortex precipitation reactor for nuclear energy applications. 21st International Symposium on Industrial Crystallization, Aug 2021, Potsdam, Germany. ⟨hal-03334748⟩
  • Maya Khellaf, C. Charcosset, Denis Mangin, E Chabanon. Reverse antisolvent crystallization using membrane pervaporation: application to L-Glutamic Acid. ISIC, Aug 2021, Postdam (Allemagne), Germany. ⟨hal-04049444⟩
  • Małgorzata Tarnowska, Yves Chevalier, Stéphanie Briançon, Claire Bordes, Jacqueline Resende de Azevedo, et al.. Skin absorption of mixed halide anions from concentrated aqueous solutions. European Journal of Pharmaceutical Sciences, 2021, pp.105985. ⟨10.1016/j.ejps.2021.105985⟩. ⟨hal-03330438⟩
  • Claire Bordes, Marie‐alexandrine Bolzinger, Myriam El Achak, Fabrice Pirot, Delphine Arquier, et al.. Formulation of Pickering emulsions for the development of surfactant‐free sunscreen creams. International Journal of Cosmetic Science, 2021, 43 (4), pp.432-445. ⟨10.1111/ics.12709⟩. ⟨hal-03330435⟩
  • Meryem Belkilani, Maryam Shokouhi, Carole Farre, Yves Chevalier, Sylvain Minot, et al.. Surface Plasmon Resonance Monitoring of Mono-Rhamnolipid Interaction with Phospholipid-Based Liposomes. Langmuir, 2021, 37 (26), pp.7975-7985. ⟨10.1021/acs.langmuir.1c00846⟩. ⟨hal-03282399⟩

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