Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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970 documents

  • Noureddine Lebaz, Nida Sheibat-Othman. Population balance modelling of single and double emulsions preparation using static mixers. 7th International Conference on Population Balance Modelling, May 2022, Lyon, France. ⟨hal-03668994⟩
  • Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Isabelle Ramière, Denis Mangin, Murielle Bertrand. Steady state population balance solution: application to neodymium oxalate precipitation in a vortex reactor. 7th International Conference on Population Balance Modelling, May 2022, Lyon, France. ⟨hal-03669016⟩
  • Soumaya Kouki, Najeh Jaoued-Grayaa, Amira Anene, Emmanuel Beyou, Yves Chevalier, et al.. The enhanced adsorption properties of molecular imprinted polymer material prepared using nitroxide-mediated Radical Deactivation Reversible Polymerization. Polymer, 2022, 249, pp.124841. ⟨10.1016/j.polymer.2022.124841⟩. ⟨hal-03654008⟩
  • Mariane Massufero Vergilio, Laura Moretti Aiello, Andreza Sonego Furlan, Amanda Costa Caritá, Jaqueline Rezende Azevedo, et al.. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound. Journal of Cosmetic Dermatology, 2022, 21 (10), pp.4921-4926. ⟨10.1111/jocd.14892⟩. ⟨hal-03835488⟩
  • Barthélémy Brunier, Yves Chevalier, Elodie Bourgeat-Lami, Nida Sheibat-Othman. Modeling polystyrene homogeneous-coagulative nucleation in Pickering emulsion polymerization. Macromolecular Reaction Engineering, 2022, 7 (8), pp.2200016. ⟨10.1002/mren.202200016⟩. ⟨hal-03762901⟩
  • Fouad Azizi, Walid Abou-Hweij, Noureddine Lebaz, Nida Sheibat-Othman. A numerical evaluation of flows through an SMX-Plus mixer. Chemical Engineering Research and Design, 2022, 178, pp.382-394. ⟨10.1016/j.cherd.2021.12.030⟩. ⟨hal-03518109⟩
  • Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Isabelle Ramière, Sophie Lalleman, Denis Mangin, et al.. Fixed point convergence and acceleration for steady state population balance modelling of precipitation processes: application to neodymium oxalate. Chemical Engineering Research and Design, 2022, 177, pp.767-777. ⟨10.1016/j.cherd.2021.11.030⟩. ⟨hal-03457230⟩
  • Khawla Mili, Zouhour Hsine, Yves Chevalier, Souhaira Hbaieb, Rym Mlika. ZnS quantum dots as fluorescence sensor for quantitative detection of tetracycline. Optical Materials, 2022, 125, pp.112103. ⟨10.1016/j.optmat.2022.112103⟩. ⟨hal-03575409⟩
  • Merymene Boukadida, Amira Anene, Najeh Jaoued-Grayaa, Yves Chevalier, Souhaira Hbaieb. Choice of the functional monomer of molecularly imprinted polymers: Does it rely on strong acid-base or hydrogen bonding interactions?. Colloid and Interface Science Communications, 2022, 50, pp.100669. ⟨10.1016/j.colcom.2022.100669⟩. ⟨hal-03806421⟩
  • Tanmoy Kanti Deb, Noureddine Lebaz, Mahir Sinan Ozdemir, Ruxandra Govoreanu, Adel Mhamdi, et al.. Monitoring and Modeling of Creaming in Oil-in-Water Emulsions. Industrial and engineering chemistry research, 2022, 61 (13), pp.4638-4647. ⟨10.1021/acs.iecr.1c04722⟩. ⟨hal-03633657⟩

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