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Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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    970 documents

    • Wei Liao, Abdelhamid Elaïssari, Emilie Dumas, Adem Gharsallaoui. Effect of trans-cinnamaldehyde or citral on sodium caseinate: Interfacial rheology and fluorescence quenching properties. Food Chemistry, 2023, 400, pp.134044. ⟨10.1016/j.foodchem.2022.134044⟩. ⟨hal-03996449⟩
    • Zouhair Ait-Touchente, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Noureddine Lebaz, et al.. Exploring the Versatility of Microemulsions in Cutaneous Drug Delivery: Opportunities and Challenges. Nanomaterials, 2023, 13 (10), pp.1688. ⟨10.3390/nano13101688⟩. ⟨hal-04102192⟩
    • Thibault Massias, Suenia de Paiva Lacerda, Jacqueline Resende de Azevedo, Jean‐jacques Letourneau, Philomène dos Santos, et al.. A proof-of-concept study of coupled supercritical CO2-assisted processes to produce solid self-assembled drug delivery systems (S-SADDS). Journal of Crystal Growth, 2023, 616, pp.127245. ⟨10.1016/j.jcrysgro.2023.127245⟩. ⟨hal-04094870⟩
    • Thibault Massias, Suenia de Paiva Lacerda, Jacqueline Resende de Azevedo, Jean‐jacques Letourneau, Marie-Alexandrine Bolzinger, et al.. Supercritical carbon dioxide solubility measurement and modelling for effective size reduction of nifedipine particles for transdermal application. International Journal of Pharmaceutics, 2023, 630, pp.122425. ⟨10.1016/j.ijpharm.2022.122425⟩. ⟨hal-03875943⟩
    • Eslam Elkalla, Sumera Khizar, Mohamad Tarhini, Noureddine Lebaz, Nadia Zine, et al.. Core-Shell Micro/Nanocapsules: From Encapsulation to Applications. Journal of Microencapsulation, 2023, 40 (3), pp.125-156. ⟨10.1080/02652048.2023.2178538⟩. ⟨hal-03978204⟩
    • Narimane Lammari, Mehdi Louaer, Ouahida Louaer, Chawki Bensouici, Ahmed Zermane, et al.. Nanoparticles encapsulating sesame seeds (Sesamum indicum) oil: Physicochemical, antioxidant and enzymatic inhibition properties. Journal of Drug Delivery Science and Technology, 2023, 79, pp.104003. ⟨10.1016/j.jddst.2022.104003⟩. ⟨hal-03996456⟩
    • Silvia Breusa, Jean‐guy Delcros, Eloise Thomas, Serena Zilio, Diana Marcela Hernandez Palomino, et al.. Monoclonal antibodies decorated nanoparticles for the treatment of triple negative breast cancer. SFNano Annual Meeting, Dec 2022, Strasbourg, France. ⟨hal-03989500⟩
    • Noureddine Lebaz, Nida Sheibat-Othman. Population balance modelling of a continuous static mixer-based emulsification process. Chemical Engineering Research and Design, 2022, 188, pp.645-654. ⟨10.1016/j.cherd.2022.10.022⟩. ⟨hal-03815945⟩
    • Carla Kalakech, C. Charcosset, Mathias Monnot, Denis Mangin, E. Gagnière, et al.. Continuous and intensified membrane crystallization process : quality control of an active pharmaceutical ingredient. Euromembrane, Nov 2022, Sorrento, Italy. ⟨hal-04050130⟩
    • Eslam Elkalla, Sumera Khizar, Nadia Zine, Nicole Jaffrezic-Renault, Noureddine Lebaz, et al.. Elaboration of iron oxide capsules for lab-on-a-chip and microsystems use. 12ème Journées Maghreb-Europe: Matériaux et applications aux dispositifs et capteurs, Nov 2022, Monastir, Tunisia. ⟨hal-03859546⟩

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