Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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970 documents

  • Marie-Noëlle Erout, Abdelhamid Elaïssari, Christian Pichot, Marie-France Llauro. Radical-initiated copolymers of N-vinyl pyrrolidone and N-acryloxy succinimide: kinetic and microstructure studies. Polymer, 1996, 37 (7), pp.1157-1165. ⟨10.1016/0032-3861(96)80842-1⟩. ⟨hal-02091114⟩
  • Abdelhamid Elaïssari, Guy Chauveteau, Clarisse Huguenard, Emile Pefferkorn. Surface Area Exclusion Chromatography: Influence of Localized and Mobile Adsorption Processes. Journal of Colloid and Interface Science, 1995, 173 (1), pp.221-230. ⟨10.1006/jcis.1995.1317⟩. ⟨hal-02091033⟩
  • E. Pefferkorn, A. Elaissari, C. Huguenard. Rate Limiting Processes in Diblock Copolymer Adsorption at Solid-Liquid Interfaces. Journal of Macromolecular Science Part A Pure and Applied Chemistry, 1992, 29 (sup2), pp.147-153. ⟨10.1080/10101329208054576⟩. ⟨hal-02077100⟩
  • A. Elaissari, A Haouam, C Huguenard, E. Pefferkorn. Kinetic factors in polymer adsorption at solid/liquid interfaces. Methods of study of the adsorption mechanism. Journal of Colloid and Interface Science, 1992, 149 (1), pp.68-83. ⟨10.1016/0021-9797(92)90392-Y⟩. ⟨hal-02077092⟩
  • A. Elaissari, E. Pefferkorn. Colloid aggregation in the presence of polymers. Effects of mobility and reactivity of clusters on the flocculation kinetics. Journal of Chemical Physics, 1991, 95 (4), pp.2919-2926. ⟨10.1063/1.460894⟩. ⟨hal-02077068⟩
  • R. Varoqui, A. Johner, A. Elaissari. Conformation of weakly charged polyelectrolytes at a solid–liquid interface. Journal of Chemical Physics, 1991, 94 (10), pp.6873-6878. ⟨10.1063/1.460267⟩. ⟨hal-02077071⟩
  • A. Elaissari, E. Pefferkorn. Aggregation modes of colloids in the presence of block copolymer micelles. Journal of Colloid and Interface Science, 1991, 143 (2), pp.343-355. ⟨10.1016/0021-9797(91)90268-D⟩. ⟨hal-02077062⟩
  • A. Elaissari, E. Pefferkorn. Polyelectrolyte induced aggregation of latex particles: Influence of the structural relaxation of adsorbed macromolecules on the colloid aggregation mode. Journal of Colloid and Interface Science, 1991, 141 (2), pp.522-533. ⟨10.1016/0021-9797(91)90349-D⟩. ⟨hal-02077055⟩
  • S. Stoll, A. Elaissari, E. Pefferkorn. Fractal dimensions of latex aggregates: Correlation between hydrodynamic radius and cluster size. Journal of Colloid and Interface Science, 1990, 140 (1), pp.98-104. ⟨10.1016/0021-9797(90)90326-J⟩. ⟨hal-02077042⟩
  • Yves Chevalier. Measurement of coupling constants in broad multiplets. Magnetic Resonance in Chemistry, 1986, 24 (5), pp.404-408. ⟨10.1002/mrc.1260240503⟩. ⟨hal-02847598⟩

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