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Phamaceutical Engineering


Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.

Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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    964 documents

    • Barthélémy Brunier, Yves Chevalier, Elodie Bourgeat-Lami, Nida Sheibat-Othman. Modeling polystyrene homogeneous-coagulative nucleation in Pickering emulsion polymerization. Macromolecular Reaction Engineering, 2022, 7 (8), pp.2200016. ⟨10.1002/mren.202200016⟩. ⟨hal-03762901⟩
    • Fouad Azizi, Walid Abou-Hweij, Noureddine Lebaz, Nida Sheibat-Othman. A numerical evaluation of flows through an SMX-Plus mixer. Chemical Engineering Research and Design, 2022, 178, pp.382-394. ⟨10.1016/j.cherd.2021.12.030⟩. ⟨hal-03518109⟩
    • Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Isabelle Ramière, Sophie Lalleman, Denis Mangin, et al.. Fixed point convergence and acceleration for steady state population balance modelling of precipitation processes: application to neodymium oxalate. Chemical Engineering Research and Design, 2022, 177, pp.767-777. ⟨10.1016/j.cherd.2021.11.030⟩. ⟨hal-03457230⟩
    • Khawla Mili, Zouhour Hsine, Yves Chevalier, Souhaira Hbaieb, Rym Mlika. ZnS quantum dots as fluorescence sensor for quantitative detection of tetracycline. Optical Materials, 2022, 125, pp.112103. ⟨10.1016/j.optmat.2022.112103⟩. ⟨hal-03575409⟩
    • Tanmoy Kanti Deb, Noureddine Lebaz, Mahir Sinan Ozdemir, Ruxandra Govoreanu, Adel Mhamdi, et al.. Monitoring and Modeling of Creaming in Oil-in-Water Emulsions. Industrial and engineering chemistry research, 2022, 61 (13), pp.4638-4647. ⟨10.1021/acs.iecr.1c04722⟩. ⟨hal-03633657⟩
    • Merymene Boukadida, Amira Anene, Najeh Jaoued-Grayaa, Yves Chevalier, Souhaira Hbaieb. Choice of the functional monomer of molecularly imprinted polymers: Does it rely on strong acid-base or hydrogen bonding interactions?. Colloid and Interface Science Communications, 2022, 50, pp.100669. ⟨10.1016/j.colcom.2022.100669⟩. ⟨hal-03806421⟩
    • Noureddine Lebaz, Fouad Azizi, Nida Sheibat-Othman. Modeling Droplet Breakage in Continuous Emulsification Using Static Mixers in the Framework of the Entire Spectrum of Turbulent Energy. Industrial and engineering chemistry research, 2022, 61 (1), pp.541-553. ⟨10.1021/acs.iecr.1c03529⟩. ⟨hal-03522969⟩
    • Chaima Nasraoui, Najeh Jaoued-Grayaa, Laurent Vanoye, Yves Chevalier, Souhaira Hbaieb. Development of molecularly imprinted polymer for the selective recognition of the weakly interacting fenamiphos molecule. European Polymer Journal, 2022, 177, pp.111441. ⟨10.1016/j.eurpolymj.2022.111441⟩. ⟨hal-03806439⟩
    • Mouna Derbali, Taoufik Soltani, Ahlem Guesmi, Naoufel Ben Hamadi, Erwann Jeanneau, et al.. Synthesis, thermal, dielectric and electro-optic properties of new series of fluorinated hydrogen-bonded liquid crystals. Journal of Molecular Liquids, 2022, 367, pp.120510. ⟨10.1016/j.molliq.2022.120510⟩. ⟨hal-03821253⟩
    • Maroua Ben Abdelkader, Nedra Azizi, Claire Bordes, Mustapha Majdoub, Yves Chevalier. Optimisation of fragrance finishing on cotton by grafting of β-cyclodextrin based microcapsules: Application of the experimental design methodology. Materials Science-Poland, 2021, 39 (4), pp.555-569. ⟨10.2478/msp-2021-0044⟩. ⟨hal-03674696⟩

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