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Phamaceutical Engineering

GEPHARM

Key words : Nanoparticles, microparticles, Pickering  emulsions, microemulsions, liposomes, skin permeation, membrane processes, freeze drying, spray drying, spray cooling, tableting, powder, drying, hybrid particles, colloids, in vitro diagnostic, environmental analysis

The LAGEPP (Laboratory of Automatic Control, Chemical and pharmaceutical  engineering)  is a research laboratory of the University Lyon 1 and the French national Institute for scientific research (CNRS UMR 5007). It develops pluridisciplinary research in chemical engineering, pharmaceutical engineering and biochemical processes. The LAGEPP gathers strong  pluridisciplinary competences in close collaboration with national and international research and development centers in industry or in academia.

The “pharmaceutical engineering” group has its strong expertise in drug delivery. This team is mainly working on the formulation of drug delivery systems for topical or parenteral  administration and diagnostic applications. The research encompasses several scientific domains and a huge part is devoted to physical chemistry and formulation: development of new drug delivery systems, physical chemistry properties and biological in vitro evaluation. Studies about skin behavior of drug delivery systems devoted to cosmetic or dermopharmaceutic applications are particularly developed, the LAGEP being equipped with high performance tools for in vitro skin assessment.


Three kinds of research works are carried out in the laboratory:
– Physico-chemistry and formulation: search for new drug delivery systems, characterization of their physico-chemical properties and in vitro biopharmaceutical evaluation. Encapsulation of drugs, contrast agents, actives… in polymeric micro/nanoparticles.
– Development of encapsulation processes and drying processes dedicated to particulate systems. Membrane processes are developed due to their ability to form calibrated emulsions and particles with a  continuous working. Drying of micro and nanoparticles is essential to guarantee the stability of these systems and their long term storage. Freeze drying and spray drying processes are studied.
– Development of solid dosage forms: tableting, drugs polymorphism, characterization spectroscopic characterization, controlled release.
– Bionanotechnology in vitro. Synthesis of colloidal reactive particles as biomolecules extraction support, as biological tracer, as transport systems…Interaction of biomolecules with these colloids.

Director of the Pharmaceutical Engineering, Professeur Bolzinger

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    958 documents

    • Jean Tallon, Barbara Browning, Emilie Gagnière, Claire Bordes, Franck Bardin, et al.. Experimental study on calcium carbonate phase transition from amorphous to crystalline forms in a reverse emulsion. Journal of Crystal Growth, 2023, 610, pp.127152. ⟨10.1016/j.jcrysgro.2023.127152⟩. ⟨hal-04039608⟩
    • Malek Fouzai, Philippe Dieudonné-George, Ahlem Guesmi, Naoufel Ben Hamadi, Youssef Arfaoui, et al.. Polar nematic phase in short-chained fluorinated hydrogen-bonded liquid crystals. Journal of Molecular Liquids, 2023, 375, pp.121307. ⟨10.1016/j.molliq.2023.121307⟩. ⟨hal-03978339⟩
    • Mathis Benyaya, Marie-Alexandrine Bolzinger, Yves Chevalier, Claire Bordes. Formulation of polymeric particles with controlled charges by alkaline tempering. Polymer, 2023, 272, pp.125838. ⟨10.1016/j.polymer.2023.125838⟩. ⟨hal-04027790⟩
    • Merymene Boukadida, Najeh Jaoued-Grayaa, Amira Anene, Yves Chevalier, Souhaira Hbaieb. Effect of cross-linking agents on the adsorption of histamine on molecularly imprinted polyacrylamide. Polymer, 2023, 268, pp.125724. ⟨10.1016/j.polymer.2023.125724⟩. ⟨hal-03955548⟩
    • Khawla Mili, Zouhour Hsine, Yves Chevalier, Gilles Ledoux, Rym Mlika. Application of thiol capped ZnS quantum dots as a fluorescence probe for determination of tetracycline residues. Solid State Communications, 2023, 360, pp.115040. ⟨10.1016/j.ssc.2022.115040⟩. ⟨hal-03905050⟩
    • Sumera Khizar, Eslam Elkalla, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, et al.. Magnetic nanoparticles: multifunctional tool for cancer therapy. Expert Opinion on Drug Delivery, 2023, 20 (2), pp.189-204. ⟨10.1080/17425247.2023.2166484⟩. ⟨hal-03996447⟩
    • Maroua Ben Abdelkader, Nedra Azizi, Ayda Baffoun, Claire Bordes, Yves Chevalier, et al.. Application of an experimental design methodology for the optimization of cosmetotextile impregnation process by β-cyclodextrin based microcapsules. Journal of the Textile Institute, 2023, 114 (2), pp.314-322. ⟨10.1080/00405000.2022.2031710⟩. ⟨hal-03951166⟩
    • Wei Liao, Abdelhamid Elaïssari, Emilie Dumas, Adem Gharsallaoui. Effect of trans-cinnamaldehyde or citral on sodium caseinate: Interfacial rheology and fluorescence quenching properties. Food Chemistry, 2023, 400, pp.134044. ⟨10.1016/j.foodchem.2022.134044⟩. ⟨hal-03996449⟩
    • Narimane Lammari, Hadjira Rabti, Ouahida Louaer, Abdelhamid Elaïssari, Abdeslam Hassen Meniai. Encapsulation of bioactive compunds: Role of nanotechnology. Principles of Biomaterials Encapsulation : Volume One, Elsevier, pp.39-65, 2023, ⟨10.1016/B978-0-323-85947-9.00007-8⟩. ⟨hal-03996452⟩
    • Thibault Massias, Suenia de Paiva Lacerda, Jacqueline Resende de Azevedo, Jean‐jacques Letourneau, Marie-Alexandrine Bolzinger, et al.. Supercritical carbon dioxide solubility measurement and modelling for effective size reduction of nifedipine particles for transdermal application. International Journal of Pharmaceutics, 2023, 630, pp.122425. ⟨10.1016/j.ijpharm.2022.122425⟩. ⟨hal-03875943⟩

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